To Compare the Role of Glibenclamide and Pioglitazone Drugs in Type 11 Non- Insulin Dependent Diabetes Mellitus Patients
heart failure.Liver failure abd death.Current Thiazoldinediones don not appear to pose the same effects on the liver although there have been a few reports of liver injury.
In patients with dietry failur the choice of a sulfonylurea agent or insulin therapy has been controversial and empric in favour of insulin therapy are the studies, who reported marked improvement post receptor diagnostic after intensive short term therapy in untreated type 2 diabetes mellitus (Scarlett et al,1984) Sulfonylureas further classified into two groups or generations based on their potency,duration,drug interaction,side effects profiles. Sulfonylureas enhance insulin action in cells in culture and stimulate the synthesis of glucose transporters (Jacobes et al 1998).A sulfonylurea drug should normally be the insulin secretagogue of choice, NICE (National Institute for Clinical Excellence) also recommends that a generic ,drug should be perscribed (Scsade et al1998).
RESEARCH DESIGN AND MATERIAL AND METHODS:
This study was conducted in the deprtment of Pharmacololgy and Therapeutics,Basic Medical Science Institute,Jinnah,Postgraduate Medical Centre,karachi under kind supervision od DRr:GhulamRsool Mashori,Associate Professoer and Head OF Department Of Pharmacology and Therapeutics in colloboration with Medical Outpatient Department Unit111 and Filter Clinic, Medical Department, JPMC,Karachi.
Seventy NIDDM (type-II)diabetic patients were initially enrolled in the study from the filter clinic/ out patient department Medical Unit III ,and diabetic clinic.Out of this 60 diabetic patients were associated in whole period of study, remaining 10 patients were dropped due to poor comlpiance or change in residential place.All the patients were divided in two main groups,groupI and in group II these patients were selected in this study according of inclusion and exclusion criteria.
INCLUSION CRITERIA
:
Newly diagnose patients of non Insulin Dependent Diabtes Mellitus.
Diagnsed patients of diabetes also including having no any history medication.
Having either sex of age between 30 to 60 years.
Diagnosed patients who were Non Insulin Depedent Diabetes Mellitus who were treated with Pioglitazone.
Diagnosed patients who were Non Imsulin Depedent Mellitus, who were treated with drug Glibenclamide.
EXCLUSION CRIRERIA
:
Patients suffering from blood pressure.
Patients suffering from liver disease.
Patients suffering from cardiac disease.
Pregnancies and lactating women.
Patient suffering from renal disorders.
Patients having serious complications.
MATERIAL:
Lacets.
Lancet Hlder(Abbots easy touch TM2 lot 03 Asee).
Glucometer(Medisense) optilim one touch(Abbotts).
Blood glucose nest trpis (IVD for Invitro diagnostic use (Abbott Labortries,Medisense UK Ltd,Abigngdon,Ox14ITR,Masde in UK). Stored between minimum 30?, (4°-30° C) and Maximum 40°C (39°-86°F).
Weight Machine Model No 1101 Lot No.312. TANTIATA.
DRUGS
Tab:Daonil 5 mg (Aventis Pharma)
Drug category:Sulphonylurea.
Generic Name: Glibenclamide.
MFGLIC:No.000007 RegistrationNO.000220
MFG Date:0-06
EXP Date:7-10
Lot NO:B230
Tab:piozer (Hilton Pharm) PvtLTd.
Tab:Poizer 15mg
Drug category:Thaiazolinedione.
Generic Name:Pioglitazone Hydrochloride.
MFG LIC: O.000136 Registration No.03270
MFG Date:3-06
EXP Date:3-o9
Lot No:6287
Tab: Poizer (Hilton Pharma)pvt ltd.
PARAMETERS:
Fasting Blood Sugar (FBS).
Random Blood Sugar (RBS).
Weight.
Key words:Diabetes mellitus,Non-insulin diabetes mellitus,Insulin depedent diabetes mellitus, Daonil,poizer,Insulin.
RESULTS:
Table 1
Weight and Blood Sugar level observed on baseline day 0
In group1 and group11
Group 1
Group 11