If So Many Recreational Drugs Work With Dopamine, Why Do They All Give Different “highs”?

Question by Derek F: If so many recreational drugs work with dopamine, why do they all give different “highs”?
I am doing a project on this for biology and it struck me that marijuana, heroin, cocaine, meth and many more all inhibit dopamine neurotransmitters, so that the neuron takes up the same dopamine molecules over and over again, overstimulating the cell.

My question is, why do they have different highs if they all use dopamine? Heroin and cocaine using the same hormone confuses me greatly.

Best answer:

Answer by Deep Thinker
It all involves the particular drugs active ingredient. It may inhibit dopamine neurotransmitters but what other chemicals are involved and how do they manifest from a physical standpoint, increased or decreased heart rate and etc. You would really have to research each individual drug to see how and why it works. It is a very interesting question that i may investigate myself. Interesting indeed.

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