Evaluation of Modafinil as a Cognitive Enhancer


 

Evaluation of Modafinil as a cognitive enhancer – www.studydrugs.net Modafinil is an analeptic drug approved by the US Food and Drug Administration (FDA) for the treatment of narcolepsy, shift work sleep disorder and excessive daytime sleepiness associated with obstructive sleep apnea. Increasing numbers of students use modafinil. The benefits of modafinil as a “smart drug” or neuroenhancer are modest at best. But its consumption at several leading British universities is quite common among students seeking a competitive edge in exams, where drug-testing is not yet routine. Reports of modafinil-popping dons suggest smart-drug use is creeping up the academic foodchain too. Despite extensive research into the interaction of modafinil with a large number of neurotransmitter systems, a precise mechanism or set of mechanisms of action remains unclear. It seems that modafinil, like other stimulants, increases the release of monoamines, specifically the catecholamines norepinephrine and dopamine, from the synaptic terminals. However, modafinil also elevates hypothalamic histamine levels, leading some researchers to consider Modafinil a “wakefulness promoting agent” rather than a classic amphetamine-like stimulant (as evidenced by the difference in c-Fos distribution caused by modafinil as compared to amphetamine). Despite modafinil’s histaminergic action, it still partially shares the actions of amphetamine-class stimulants due to its effects on norepinephrine and dopamine. Although there was some speculation modafinil could be

 

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