What Is the Mechanism of Action for the Amphetamine Type Anorexic Drugs?

Question by James, Sr.: What is the mechanism of action for the amphetamine type anorexic drugs?

Best answer:

Answer by M A SALAM
Amphetamine can modify the action of dopamine and noradrenaline in the brain. At high doses, amphetamine increases the concentration of dopamine in the synaptic cleft in 4 ways:
(1) it can bind to the pre-synaptic membrane of dopaminergic neurones and induce the release of dopamine from the nerve terminal;
(2) amphetamine can interact with dopamine containing synaptic vesicles, releasing free dopamine into the nerve terminal;
(3) amphetamine can bind to monoamine oxidase in dopaminergic neurones and prevent the degradation of dopamine, leaving free dopamine in the nerve terminal; and
(4) amphetamine can bind to the dopamine re-uptake transporter, causing it to act in reverse and transport free dopamine out of the nerve terminal. High-dose amphetamine has a similar effect on noradrenergic neurones; it can induce the release of noradrenaline into the synaptic cleft and inhibit the noradrenaline re-uptake transporter.
[Amphetamine inhibits uptake and causes release of dopamine from presynaptic terminals. Amphetamine can act on both vesicular storage of dopamine and directly on the dopamine transporter (DT). ]
In the above stated ways, amphetamine relieves anorexia and improves appetite.

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